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Description
Mouse Anti-Human CD154 Antibody (S-R579)Product Specification Host Mouse Antigen CD154 Synonyms CD40 ligand; CD40 L; T cell antigen Gp39; TNF related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40LG; CD40L; TNFSF5; TRAP Location Cell membrane Accession P29965 Clone Number S R579 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | CD154 |
| Synonyms | CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40LG; CD40L; TNFSF5; TRAP |
| Location | Cell membrane |
| Accession | P29965 |
| Clone Number | S-R579 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD154, also known as CD40 ligand (CD40L), is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is predominantly expressed on activated CD4+ T cells, but can also be found on other immune cells such as monocytes, natural killer cells, and platelets. CD154 interacts with CD40, a receptor expressed on antigen-presenting cells (APCs), B cells, and other immune cells, and is crucial for T cell activation, B cell proliferation and differentiation, and the production of various cytokines. This interaction is essential for the adaptive immune response, including B cell class switching, germinal center formation, and the generation of memory B cells. Mutations in the CD154 gene can lead to X-linked hyper-IgM syndrome, an immunodeficiency characterized by a lack of IgG, IgA, and IgE antibodies. Additionally, CD154 is involved in various inflammatory processes and has been implicated in conditions such as atherosclerosis.
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Exchange/Return Notes
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